Berberine
Plant compound studied for metabolic support.
4.2 Strong evidence
Last updated: 2025-12-10Berberine is a bioactive compound found in several plants. It is best known for research on blood sugar and lipid markers.
Evidence snapshot
- - Multiple human trials for glucose and lipid support.
- - Effects depend on dose and consistency.
- - Not a substitute for medical treatment.
Common uses
- - Metabolic support
- - Blood sugar management
- - Lipid markers
Typical dose
500 mg, 2-3 times per day with meals
Common forms
- - Capsule
- - Tablet
Safety notes
- - Discuss use with a professional if pregnant or nursing.
- - Start low to assess tolerance.
- - Stop use if you experience adverse effects.
Interactions
- - May interact with blood sugar or blood pressure medications.
- - Use caution with other metabolic supplements.
Pros
- - Well-studied for metabolic markers
- - Clear dosing patterns across trials
Cons
- - Can cause digestive discomfort in some people
- - Interactions possible with medications
FAQ
How long does it take to work?
Many studies track results over 8 to 12 weeks of consistent use.
Should it be taken with food?
Yes, many people take it with meals to improve tolerance.